For years there was no focus within the U.S. federal government for alternatives to animal toxicity testing. Questions coming to regulatory agencies fell upon individuals to address in the best way they could. Given this void, the ad hoc Interagency Regulatory Alternatives Group was founded by staff in a number of federal agencies in the late 1980s to coalesce efforts in the field. The group sponsored two international workshops on eye irritation, the first making proposals for change in the current (...) test method in rabbits, the second reviewing available data on in vitro alternatives. The result has been that the Organization for Economic Cooperation and Development (OECD) is considering revision of the in vivo eye irritation test guideline to incorporate a number of the workshop deliberations. However, movement of the in vitro eye irritation alternatives has been disappointing; attempts to determine their practical testing significance have thus far been unrewarding. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Joseph Priestley's Criticisms of David Hume's Philosophy RICHARD H. POPKIN ONE OF HUME'S MOST FAMOUS CRITICS, the great scientist Joseph Priestley (1733-1804), is scarcely mentioned or studied in the Hume literature.' Perhaps because of the course philosophy followed after Hume, the Scottish Common Sense critics and the German ones connected with Kant are given almost all of the attention. In this paper 1 shall try to correct this (...) oversight, and examine the background of Priestley's critique of Hume, both in terms of Priestley's scientific and religious views and in terms of Hume's influence at the time. I shall then evaluate the merits of Priestley's critique and attempt to determine whether it deserves further study or should be returned to the obscurity it has been in for almost two centuries. 2 Joseph Priestley was a nonconforming minister whose progressively radical views caused him to lose various posts. Eventually he became a millenarian, convinced that crucial signs of the end of the world were at hand: the events of the French Revolution; the purported discovery of the Lost Tribes in Afghanistan by Sir William Jones; plans or hopes for the Jews to return to Palestine and join forces with the Christians. After years of religious wanderings Priestley ended up a millenarian Unitarian, much in the tradition of Sir Isaac Newton, whose religious writing he used extensively, and of Newton's successor, William Whiston? Priestley taught science in various schools and was immensely influenced by David Hartley's Observations on Man. He found in Hartley's theory of association of ideas a naturalistic way of explaining human mental life. And in Hartley's millenarian views he located the sort of theology he was seeking. Priestly later reedited Hartley, including introductory essays about some of the more difficult aspects of his mechanistic psychology.' (Coleridge, who was deeply impressed by ' T. E. Jessop, A Bibliography of David Hume and of the Scottish Philosophy from l-)'ancis Hutcheson to Lord Balfour (New York, 1966), lists the titles of Priestley's works relevant to Hume. However, there appear to be no discussions of Priestley on Hume listed in this work or in Roland Hill, A Bibliography of David Hume from 1930 (York, 1971). E. C. Mossner, The Life of David Hume (Edinburgh, 1954), mentions Priestley's criticisms of Hume, but only as these were made in connection with criticisms of Beattie. Joseph Priestley, Memoirs of Dr. Joseph Priestley to the Year 1795, written by Himself, with a Continuation to the time of his decease by his son, Joseph Priestley, ed. T. Cooper (London, 1806). It is also of some interest that Priestley attacked Reid, Beattie, and Oswald a few years before challenging Hume. He seemed to think that he had disposed of the Scottish Philosophy for all time. Thus Priestley was certainly no part of the mainstream of Hume's opponents in Britain. See Memoirs, pp. 78-79n, and n. 16 below. ' On Priestley's career, see his Memoirs. Modern biographies deal principally with his scientific achievements and ignore or play down his theological concerns. For an extended discussion of Priestley's millenarian views, see Clarke Garrett, Respectable Folly (Baltimore, 1975), pp. 126-143. " Priestley, Hartley's Theory of the Human Mind, on the Principle of the Association of Ideas... (London, 1775). [437] 438 HISTORY OF PHILOSOPHY Hartley, probably read Priestley's edition of his works.) For the most part, Priestley wrote long and controversial works on theology. His scientific achievements stem from his friendship with Benjamin Franklin and Richard Price, who encouraged him to write a history of discoveries in electricity. Franklin provided the resources for making the equipment. On the basis of the new material in his work, Priestley was nominated to the Royal Society by Franklin and Price. s Priestley's most famous scientific works came thereafter--his discovery of oxygen and his work on how the human body used oxygen. Later still, he became entangled in a controversy with Lavoisier over the phlogiston theory, Priestley upholding it, the French chemist opposing it. 6 Priestley was also active in politics, supporting radical causes. He supported John Wilkes, of whom Hume thoroughly disapproved, and was an early... (shrink)

It is widely assumed that selection history accounts of function can support a fully reductive naturalization of functional properties. I argue that this assumption is false. A problem with the alternative causal role account of function in this context is that it invokes the teleological notion of a goal in analysing real function. The selection history account, if it is to have reductive status, must not do the same. But attention to certain cases of selection history in biology, specifically those (...) involving meiotic drive, shows that selection historical explanations are available in the case of items without any plausible function. Making contributions to goals, here fitness, must be introduced as an additional constraint in the analysis, either explicitly, or implicitly by appeal to individual functions or the selection-of/selection-for distinction. (shrink)

"The University of Missouri's rich record of accomplishment and service to Missouri, the nation, and the world is captured in this collection of photographs of campus landmarks, people, events, and Tiger spirit. Includes a history of the campus and timeli.

Two ideas govern the organisation of this collection. It is suggested that medieval philosophy is best studied as an interactive debate between thinkers of different times, and also the importance of the Ancient Greek philosophers in this field.

This paper argues that Donald Davidson’s infamous denial in “A Nice Derangement of Epitaphs” that there is any such thing as a language, though it may not be fully supported by the arguments given for it in that paper, is nonetheless entailed by his semantic views generally, according to which the literal, linguistic meaning of a speaker’s words on an occasion is determined by how the speaker intended to be understood. In favor of this view, and thus against conventional languages, (...) the paper then argues that this understanding of linguistic meaning promises, in a way the conventional view of meaning does not, to make sense of linguistic normativity. (shrink)

Donald Davidson infamously claims that belief is in its nature veridical, and that skepticism is for this reason fundamentally incoherent. To those who take the issue of external world skepticism seriously, Davidson's arguments may seem to involve a conjuring trick. In particular, his invocation of an ‘omniscient interpreter’, whose intelligibility supposedly ensures that our beliefs must be largely true, has the air of incense and lantern-rubbing about it. Davidson's claim has received considerable critical response in the literature, almost all of (...) it negative. In my view, some commentators have indeed lit on a critical and controversial lemma in Davidson's argument, but this basic result has been obscured by being presented amidst an array of other criticisms that simply make no sense from a Davidsonian point of view. The aim of this paper is to clear away some of the confusion that stands in the way of a more productive evaluation of Davidson's important claim. (shrink)

I examine the arguments Donald Davidson has offered through the years concerning the ontological bona fides of facts. In “Truth and Meaning”, Davidson uses the so-called “slingshot” argument to the effect that if true sentences refer, then they are all coreferential. Through a detailed examination of the assumptions underlying this argument, I show that, while it is effective as part of a reductio of bottom-up, reference based semantics, it has no tendency to establish the truth of its negative conclusion concerning (...) the existence of facts. Davidson also argues against facts by claiming they are of no help in the explication of truth. I claim that his repeated invocation of the slingshot in this context, as well as of arguments from other authors employing assumptions similar to the slingshot's, is inappropriate, especially in light of his own commitment to a top-down semantics — a committment inspired, ironically, by the reductio offered in “Truth and Meaning”. Davidson's other argument against truth as correspondence, namely that our grasp of facts is no better than our grasp of truths, is sound. But this argument does not show that there are no facts; it shows only that no theory of truth in terms of corre- pondence to facts can genuinely illuminate its explanandum. (shrink)

Kant distinguishes “natural ends” as exhibiting a part-whole reciprocal causal structure in virtue of which we can only conceive them as having been caused through a conception, as if by intelligent design. Here, I put pressure on Kant’s position by arguing that his view of what individuates and makes cognizable material bodies of any kind is inadequate and needs supplementation. Drawing on Spinoza, I further urge that the needed supplement is precisely the whole-part reciprocal causal structure that Kant takes to (...) be distinctive of natural ends alone. (shrink)

Donald Davidson argues that his interpretivist approach to meaning shows that accounting for the intentionality and objectivity of thought does not require an appeal, as John McDowell has urged it does, to a specifically rational relation between mind and world. Moreover, Davidson claims that the idea of such a relation is unintelligible. This paper takes issue with these claims. It shows, first, that interpretivism, contra Davidson's express view, does not depend essentially upon an appeal to a causal relation between events (...) in the world and speakers' beliefs. Second, it shows that interpretivism essentially, if implicitly, depends upon interpreters' appealing to facts taken in in perception, and that such facts are suited to provide a rational connection between mind and world. The paper then argues that none of Davidson's legitimate epistemological arguments tell against the idea that experience, in the form of the propositional contents of perception, can play a role in doxastic economy. Finally, it argues that granting experience such a role is consistent with Davidson's coherentist slogan that nothing can count as a reason for holding a belief except another belief. (shrink)

This paper is a result of remarks delivered at the 2014 conference of the Florida Philosophical Association during a book symposium on Elijah Chudnoff's Intuition.

This book presents selections from the political and social thought of the ancient West from the early sixth century BCE up to the early years of the Roman Empire and includes not only the classic philosophers, Plato, Aristotle, and Cicero, but a number of dramatists and historians as well. The range of topics these writings treat run from class conflict, through the perils of democracy and the horrors of tyranny, to the place of women in politics, while the styles range (...) from the deeply dramatic of Sophocles' Antigone and the bawdy satire of Aristophanes' Assemblywomen to Plato's Socratic dialogue Republic and Aristotle's scientific treatise Politics. The translations have been chosen, and sometimes modified, for clarity and readability, and are accompanied by introductions which set forth the historical context and trace the general lines of thought the readings develop. Frequent notes explain references to ancient lore unfamiliar to many readers. Questions for discussion accompany each reading. (shrink)

In this important collection, the editors argue that medieval philosophy is best studied as an interactive discussion between thinkers working on very much the same problems despite being often widely separated in time or place. Each section opens with at least one selection from a classical philosopher, and there are many points at which the readings chosen refer to other works that the reader will also find in this collection. There is a considerable amount of material from central figures such (...) as Augustine, Abelard, Duns Scotus, and William of Ockham, as well as extensive texts from thinkers in the medieval Islamic world. Each selection is prefaced by a brief introduction by the editors, providing a philosophical and religious background to help make the material more accessible to the reader. This edition, updated throughout, contains a substantial new chapter on medieval psychology and philosophy of mind, with texts from authors not previously represented such as John Buridan and Peter John Olivi. (shrink)

This is a collection of essays touching on four distinct areas of interest to philosophers, lawyers, and political scientists: the philosophical justification for the adversary system; the problems of truth-finding in an adversarial setting; the issue of justice in relation to social policy-making; the right to privacy.

From the neurophysiological perspective, thinking in dreaming and the quality of dream thought have been considered hallucinatory, bizarre, illogical, improbable, or even impossible. This empirical phenomenological research concentrates on testing whether dream thought can be defined as rational in the sense of an intervening mental process between sensory perception and the creation of meaning, leading to a conclusion or to taking action. From 10 individual dream journals of male participants aged 22–59 years and female participants aged 25–49 years, we delimited (...) four dreams per journal and randomly selected five thought units from each dream for scoring. The units provided a base for testing a hypothesis that the thought processes of dream construction are rational. The results support the hypothesis and demonstrate that eight fundamental rational thought processes can be applied to the dreaming process. (shrink)

The discovery and engineering of novel fluorescent proteins (FPs) from diverse organisms is yielding fluorophores with exceptional characteristics for live‐cell imaging. In particular, the development of FPs for fluorescence (or Förster) resonance energy transfer (FRET) microscopy is providing important tools for monitoring dynamic protein interactions inside living cells. The increased interest in FRET microscopy has driven the development of many different methods to measure FRET. However, the interpretation of FRET measurements is complicated by several factors including the high fluorescence background, (...) the potential for photoconversion artifacts and the relatively low dynamic range afforded by this technique. Here, we describe the advantages and disadvantages of four methods commonly used in FRET microscopy. We then discuss the selection of FPs for the different FRET methods, identifying the most useful FP candidates for FRET microscopy. The recent success in expanding the FP color palette offers the opportunity to explore new FRET pairs. (shrink)